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Nanogyroids Incorporating Multivalent Lipids: Enhanced Membrane Charge Density and Pore Forming Ability for Gene Silencing

The self-assembly of a custom-synthesized pentavalent cationic lipid (MVL5) and glycerol monooleate (GMO) with small interfering RNA (siRNA) results in the formation of a double-gyroid bicontinuous inverted cubic phase with co-localized lipid/siRNA domains as shown by synchrotron X-ray scattering an...

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Detalhes bibliográficos
Main Authors: Leal, Cecília, Ewert, Kai K., Shirazi, Rahau S., Bouxsein, Nathan F., Safinya, Cyrus R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3119580/
https://ncbi.nlm.nih.gov/pubmed/21612245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/la200679x
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