A Preclinical and Clinical Study of Lithium in Low-Grade Neuroendocrine Tumors

BACKGROUND. Low-grade neuroendocrine tumors (NETs) respond poorly to chemotherapy; effective, less toxic therapies are needed. Glycogen synthase kinase (GSK)-3β has been shown to regulate growth and hormone production in NETs. Use of lithium chloride in murine models suppressed carcinoid cell growth...

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Autores principales: Lubner, Sam J., Kunnimalaiyaan, Muthusamy, Holen, Kyle D., Ning, Li, Ndiaye, Mary, LoConte, Noelle K., Mulkerin, Daniel L., Schelman, William R., Chen, Herbert
Formato: Artigo
Lenguaje:Inglês
Publicado: AlphaMed Press 2011
Materias:
Endocrinology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3119207/
https://ncbi.nlm.nih.gov/pubmed/21393344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2010-0323
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