A Pilot Phase II Study of Valproic Acid for Treatment of Low-Grade Neuroendocrine Carcinoma

INTRODUCTION. Notch1 has been shown to be a tumor suppressor in neuroendocrine tumors (NETs). Previous in vitro studies in NET cell lines have also suggested that valproic acid (VPA), a histone deacetylase inhibitor, can induce Notch1 and that Notch1 activation correlates with a decrease in tumor ma...

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Detalhes bibliográficos
Main Authors: Mohammed, Tabraiz A., Holen, Kyle D., Jaskula-Sztul, Renata, Mulkerin, Daniel, Lubner, Sam J., Schelman, William R., Eickhoff, Jens, Chen, Herbert, LoConte, Noelle K.
Formato: Artigo
Idioma:Inglês
Publicado em: AlphaMed Press 2011
Assuntos:
Endocrinology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3121900/
https://ncbi.nlm.nih.gov/pubmed/21632454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2011-0031
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