NHE3 modulates the severity of colitis in IL-10-deficient mice

NHE3, the major intestinal Na(+)/H(+) exchanger, was shown to be downregulated and/or inhibited in patients with inflammatory bowel disease (IBD), a phenomenon believed to contribute to inflammation-associated diarrhea. NHE3(−/−) mice spontaneously develop colitis and demonstrate high susceptibility...

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Bibliografske podrobnosti
Main Authors: Larmonier, C. B., Laubitz, D., Thurston, R. D., Bucknam, A. L., Hill, F. M., Midura-Kiela, M., Ramalingam, R., Kiela, P. R., Ghishan, F. K.
Format: Artigo
Jezik:Inglês
Izdano: American Physiological Society 2011
Teme:
Inflammation/Immunity/Mediators
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3119112/
https://ncbi.nlm.nih.gov/pubmed/21415416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00073.2011
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