Enhancing AMPK activation during ischemia protects the diabetic heart against reperfusion injury

AMPK activation during ischemia helps the myocardium to cope with the deficit of energy production. As AMPK activity is considered to be impaired in diabetes, we hypothesized that enhancing AMPK activation during ischemia above physiological levels would protect the ischemic diabetic heart through A...

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Главные авторы: Paiva, Marta A., Rutter-Locher, Zoe, Gonçalves, Lino M., Providência, Luís A., Davidson, Sean M., Yellon, Derek M., Mocanu, Mihaela M.
Формат: Artigo
Язык:Inglês
Опубликовано: American Physiological Society 2011
Предметы:
Energetics and Metabolism
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3119096/
https://ncbi.nlm.nih.gov/pubmed/21421816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00707.2010
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