Hsp-27 induction requires POU4F2/Brn-3b TF in doxorubicin-treated breast cancer cells, whereas phosphorylation alters its cellular localisation following drug treatment

POU4F2/Brn-3b transcription factor (referred to as Brn-3b) is elevated in >60% of breast cancers and profoundly alters growth and behaviour of cancer cells by regulating distinct subsets of target genes. Previous studies showed that Brn-3b was required to maximally transactivate small heat shock...

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Detalhes bibliográficos
Main Authors: Fujita, Rieko, Ounzain, Samir, Wang, Alice Chun Yin, Heads, Richard John, Budhram-Mahadeo, Vishwanie Shanie
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Netherlands 2011
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3118820/
https://ncbi.nlm.nih.gov/pubmed/21279488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12192-011-0256-8
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