Immunosuppression alters disease severity in juvenile Batten disease mice

Autoantibodies to brain proteins are present in Juvenile Neuronal Ceroid Lipofuscinosis (Batten disease) patients and the Cln3(−/−) mouse model of this disease, suggesting an autoimmune component to pathogenesis. Using genetic or pharmaceutical approaches to attenuate this immune response in Cln3(−/...

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Main Authors: Seehafer, Sabrina S., Ramirez-Montealegre, Denia, Wong, Andrew MS, Chan, Chun-Hung, Castaneda, Julian, Horak, Michael, Ahmadi, Sarah M, Lim, Ming J, Cooper, Jonathan D, Pearce, David A
Format: Artigo
Language:Inglês
Published: 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3118572/
https://ncbi.nlm.nih.gov/pubmed/20937531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jneuroim.2010.08.024
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