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Immunosuppression alters disease severity in juvenile Batten disease mice
Autoantibodies to brain proteins are present in Juvenile Neuronal Ceroid Lipofuscinosis (Batten disease) patients and the Cln3(−/−) mouse model of this disease, suggesting an autoimmune component to pathogenesis. Using genetic or pharmaceutical approaches to attenuate this immune response in Cln3(−/...
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主要な著者: | , , , , , , , , , |
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フォーマット: | Artigo |
言語: | Inglês |
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2011
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オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3118572/ https://ncbi.nlm.nih.gov/pubmed/20937531 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jneuroim.2010.08.024 |
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