THE 1α,25-DIHYDROXY VITAMIN D3 RECEPTOR PREFERENTIALLY RECRUITS THE COACTIVATOR SRC-1 DURING UP-REGULATION OF THE OSTEOCALCIN GENE

Binding of 1α,25-dihydroxy vitamin D3 to the C-terminal domain (LBD) of its receptor (VDR), induces a conformational change that enables interaction of VDR with transcriptional coactivators such as the members of the p160/SRC family or the DRIP (Vitamin D Interacting Complex)/Mediator complex. These...

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Detalhes bibliográficos
Main Authors: Carvallo, Loreto, Henriquez, Berta, Olate, Juan, van Wijnen, Andre J., Lian, Jane B., Stein, Gary S., Onate, Sergio, Stein, Janet L., Montecino, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3118563/
https://ncbi.nlm.nih.gov/pubmed/17218095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsbmb.2006.12.022
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