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Intratumoral Administration of TLR4 Agonist Absorbed into a Cellular Vector Improves Anti-tumor Responses
PURPOSE: Since TLR agonists have been well characterized as DC activators, we hypothesized that the admixture of TLR4 agonist into a cellular vector could improve the anti-tumor response in vivo. EXPERIMENTAL DESIGN: GM-CSF secreting whole cell tumor cell vector (GVAX) was formulated with LPS, a TLR...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2011
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3117911/ https://ncbi.nlm.nih.gov/pubmed/21543518 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-3262 |
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