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Intratumoral Administration of TLR4 Agonist Absorbed into a Cellular Vector Improves Anti-tumor Responses

PURPOSE: Since TLR agonists have been well characterized as DC activators, we hypothesized that the admixture of TLR4 agonist into a cellular vector could improve the anti-tumor response in vivo. EXPERIMENTAL DESIGN: GM-CSF secreting whole cell tumor cell vector (GVAX) was formulated with LPS, a TLR...

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שמור ב:
מידע ביבליוגרפי
Main Authors: Davis, Meghan B., Vasquez-Dunddel, David, Fu, Juan, Albesiano, Emilia, Pardoll, Drew, Kim, Young J.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2011
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3117911/
https://ncbi.nlm.nih.gov/pubmed/21543518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-3262
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