Efficacy Study of Novel Diamidine Compounds in a Trypanosoma evansi Goat Model

Three diamidines (DB 75, DB 867 and DB 1192) were selected and their ability to cure T. evansi experimentally infected goats was investigated. A toxicity assessment and pharmacokinetic analysis of these compounds were additionally carried out. Goats demonstrated no signs of acute toxicity, when trea...

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Main Authors: Gillingwater, Kirsten, Gutierrez, Carlos, Bridges, Arlene, Wu, Huali, Deborggraeve, Stijn, Ali Ekangu, Rosine, Kumar, Arvind, Ismail, Mohamed, Boykin, David, Brun, Reto
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3117839/
https://ncbi.nlm.nih.gov/pubmed/21698106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0020836
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