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Design, Synthesis and Characterization of a Highly Effective Inhibitor for Analog-Sensitive (as) Kinases
Highly selective, cell-permeable and fast-acting inhibitors of individual kinases are sought-after as tools for studying the cellular function of kinases in real time. A combination of small molecule synthesis and protein mutagenesis, identified a highly potent inhibitor (1-Isopropyl-3-(phenylethyny...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3117834/ https://ncbi.nlm.nih.gov/pubmed/21698101 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0020789 |
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