Design, Synthesis and Characterization of a Highly Effective Inhibitor for Analog-Sensitive (as) Kinases

Highly selective, cell-permeable and fast-acting inhibitors of individual kinases are sought-after as tools for studying the cellular function of kinases in real time. A combination of small molecule synthesis and protein mutagenesis, identified a highly potent inhibitor (1-Isopropyl-3-(phenylethyny...

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Bibliografiske detaljer
Main Authors: Klein, Michael, Morillas, Montse, Vendrell, Alexandre, Brive, Lars, Gebbia, Marinella, Wallace, Iain M., Giaever, Guri, Nislow, Corey, Posas, Francesc, Grøtli, Morten
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3117834/
https://ncbi.nlm.nih.gov/pubmed/21698101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0020789
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