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Ex vivo propagation of infectious sheep scrapie agent in heterologous epithelial cells expressing ovine prion protein

Transmissible spongiform encephalopathies, or prion diseases, are fatal degenerative disorders of the central nervous system that affect humans and animals. Prions are nonconventional infectious agents whose replication depends on the host prion protein (PrP). Transmission of prions to cultured cell...

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Published in:Proc Natl Acad Sci U S A
Main Authors: Vilette, D., Andreoletti, O., Archer, F., Madelaine, M. F., Vilotte, J. L., Lehmann, S., Laude, H.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2001
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC31178/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11259656/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.061337998
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