The Loss of the p53 Activator HIPK2 Is Responsible for Galectin-3 Overexpression in Well Differentiated Thyroid Carcinomas

BACKGROUND: Galectin-3 (Gal-3) is an anti-apoptotic molecule involved in thyroid cells transformation. It is specifically overexpressed in thyroid tumour cells and is currently used as a preoperative diagnostic marker of thyroid malignancy. Gal-3 expression is downregulated by wt-p53 at the transcri...

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Detalhes bibliográficos
Main Authors: Lavra, Luca, Rinaldo, Cinzia, Ulivieri, Alessandra, Luciani, Emidio, Fidanza, Paolo, Giacomelli, Laura, Bellotti, Carlo, Ricci, Alberto, Trovato, Maria, Soddu, Silvia, Bartolazzi, Armando, Sciacchitano, Salvatore
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3117790/
https://ncbi.nlm.nih.gov/pubmed/21698151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0020665
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