Repression of the Antiapoptotic Molecule Galectin-3 by Homeodomain-Interacting Protein Kinase 2-Activated p53 Is Required for p53-Induced Apoptosis

Galectin 3 (Gal-3), a member of the β-galactoside binding lectin family, exhibits antiapoptotic functions, and its aberrant expression is involved in various aspects of tumor progression. Here we show that p53-induced apoptosis is associated with transcriptional repression of Gal-3. Previously, it h...

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Auteurs principaux: Cecchinelli, Barbara, Lavra, Luca, Rinaldo, Cinzia, Iacovelli, Stefano, Gurtner, Aymone, Gasbarri, Alessandra, Ulivieri, Alessandra, Del Prete, Fabrizio, Trovato, Maria, Piaggio, Giulia, Bartolazzi, Armando, Soddu, Silvia, Sciacchitano, Salvatore
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2006
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1489111/
https://ncbi.nlm.nih.gov/pubmed/16738336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00959-05
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