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PGC-1alpha downstream transcription factors NRF-1 and TFAM are genetic modifiers of Huntington disease
BACKGROUND: Huntington disease (HD) is an inherited neurodegenerative disease caused by an abnormal expansion of a CAG repeat in the huntingtin HTT (HD) gene. The primary genetic determinant of the age at onset (AO) is the length of the HTT CAG repeat; however, the remaining genetic contribution to...
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| Main Authors: | , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
BioMed Central
2011
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3117738/ https://ncbi.nlm.nih.gov/pubmed/21595933 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-6-32 |
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