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A systems biology approach to dynamic modeling and inter-subject variability of statin pharmacokinetics in human hepatocytes

BACKGROUND: The individual character of pharmacokinetics is of great importance in the risk assessment of new drug leads in pharmacological research. Amongst others, it is severely influenced by the properties and inter-individual variability of the enzymes and transporters of the drug detoxificatio...

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Main Authors: Bucher, Joachim, Riedmaier, Stephan, Schnabel, Anke, Marcus, Katrin, Vacun, Gabriele, Weiss, Thomas S, Thasler, Wolfgang E, Nüssler, Andreas K, Zanger, Ulrich M, Reuss, Matthias
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2011
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Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3117731/
https://ncbi.nlm.nih.gov/pubmed/21548957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1752-0509-5-66
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