A systems biology approach to dynamic modeling and inter-subject variability of statin pharmacokinetics in human hepatocytes

BACKGROUND: The individual character of pharmacokinetics is of great importance in the risk assessment of new drug leads in pharmacological research. Amongst others, it is severely influenced by the properties and inter-individual variability of the enzymes and transporters of the drug detoxificatio...

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Detalhes bibliográficos
Main Authors: Bucher, Joachim, Riedmaier, Stephan, Schnabel, Anke, Marcus, Katrin, Vacun, Gabriele, Weiss, Thomas S, Thasler, Wolfgang E, Nüssler, Andreas K, Zanger, Ulrich M, Reuss, Matthias
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3117731/
https://ncbi.nlm.nih.gov/pubmed/21548957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1752-0509-5-66
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