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A systems biology approach to dynamic modeling and inter-subject variability of statin pharmacokinetics in human hepatocytes
BACKGROUND: The individual character of pharmacokinetics is of great importance in the risk assessment of new drug leads in pharmacological research. Amongst others, it is severely influenced by the properties and inter-individual variability of the enzymes and transporters of the drug detoxificatio...
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| 主要な著者: | , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
BioMed Central
2011
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3117731/ https://ncbi.nlm.nih.gov/pubmed/21548957 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1752-0509-5-66 |
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