A systems biology approach to dynamic modeling and inter-subject variability of statin pharmacokinetics in human hepatocytes

BACKGROUND: The individual character of pharmacokinetics is of great importance in the risk assessment of new drug leads in pharmacological research. Amongst others, it is severely influenced by the properties and inter-individual variability of the enzymes and transporters of the drug detoxificatio...

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Hlavní autoři: Bucher, Joachim, Riedmaier, Stephan, Schnabel, Anke, Marcus, Katrin, Vacun, Gabriele, Weiss, Thomas S, Thasler, Wolfgang E, Nüssler, Andreas K, Zanger, Ulrich M, Reuss, Matthias
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2011
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3117731/
https://ncbi.nlm.nih.gov/pubmed/21548957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1752-0509-5-66
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