Alkyl phosphotriester modified oligodeoxyribonucleotides. V. Synthesis and absolute configuration of Rp and Sp diastereomers of an ethyl phosphotriester (Et) modified EcoRI recognition sequence, d[GGAA(Et)TTCC]. A synthetic approach to regio- and stereospecific ethylation-interference studies.

Protected deoxynucleoside 3'-O-ethyl-N,N-diisopropylphosphoramidite reagents were prepared for use in the automated synthesis of ethyl phosphotriester (Et) modified oligonucleotides. The title diastereomers were separated by reversed-phase HPLC, and chirality at phosphorus was assigned by an improve...

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Bibliografiske detaljer

Udgivet i:	Nucleic Acids Res
Principais autores:	Gallo, K A, Shao, K L, Phillips, L R, Regan, J B, Koziolkiewicz, M, Uznanski, B, Stec, W J, Zon, G
Format:	Artigo
Sprog:	Inglês
Udgivet:	Oxford University Press 1986
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC311759/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3020514/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/14.18.7405
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