Phosphorothioate-modified oligodeoxyribonucleotides. III. NMR and UV spectroscopic studies of the Rp-Rp, Sp-Sp, and Rp-Sp duplexes, [d(GGSAATTCC)]2, derived from diastereomeric O-ethyl phosphorothioates.

2D-NOE and 1H NMR chemical shift data obtained for the title oligonucleotides were compared with similar data previously reported [Broido et al. (1985) Eur. J. Biochem. 150, 117-128] for the unmodified "parent" structure, [d(GGAATTCC)]2. The spectroscopically detectable structural perturbations caus...

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Detalles Bibliográficos

Publicado en:	Nucleic Acids Res
Principais autores:	LaPlanche, L A, James, T L, Powell, C, Wilson, W D, Uznanski, B, Stec, W J, Summers, M F, Zon, G
Formato:	Artigo
Idioma:	Inglês
Publicado:	Oxford University Press 1986
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC311930/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3786144/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/14.22.9081
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