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Phosphorothioate-modified oligodeoxyribonucleotides. III. NMR and UV spectroscopic studies of the Rp-Rp, Sp-Sp, and Rp-Sp duplexes, [d(GGSAATTCC)]2, derived from diastereomeric O-ethyl phosphorothioates.

2D-NOE and 1H NMR chemical shift data obtained for the title oligonucleotides were compared with similar data previously reported [Broido et al. (1985) Eur. J. Biochem. 150, 117-128] for the unmodified "parent" structure, [d(GGAATTCC)]2. The spectroscopically detectable structural perturba...

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Main Authors: LaPlanche, L A, James, T L, Powell, C, Wilson, W D, Uznanski, B, Stec, W J, Summers, M F, Zon, G
格式: Artigo
語言:Inglês
出版: 1986
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC311930/
https://ncbi.nlm.nih.gov/pubmed/3786144
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