Alkyl phosphotriester modified oligodeoxyribonucleotides. V. Synthesis and absolute configuration of Rp and Sp diastereomers of an ethyl phosphotriester (Et) modified EcoRI recognition sequence, d[GGAA(Et)TTCC]. A synthetic approach to regio- and stereospecific ethylation-interference studies.

Protected deoxynucleoside 3'-O-ethyl-N,N-diisopropylphosphoramidite reagents were prepared for use in the automated synthesis of ethyl phosphotriester (Et) modified oligonucleotides. The title diastereomers were separated by reversed-phase HPLC, and chirality at phosphorus was assigned by an im...

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Bibliografske podrobnosti
Main Authors: Gallo, K A, Shao, K L, Phillips, L R, Regan, J B, Koziolkiewicz, M, Uznanski, B, Stec, W J, Zon, G
Format: Artigo
Jezik:Inglês
Izdano: 1986
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC311759/
https://ncbi.nlm.nih.gov/pubmed/3020514
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