Superior anti-malarial immunity after vaccination with late-liver-stage arresting genetically attenuated parasites

While subunit vaccines have shown partial efficacy in clinical trials, radiation-attenuated-sporozoites (RAS) remain the “gold-standard” for sterilizing protection against Plasmodium-infection in human vaccinees. The variability in immunogenicity and replication introduced by the extensive, random D...

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Detalhes bibliográficos
Main Authors: Butler, Noah S., Schmidt, Nathan W., Vaughan, Ashley M., Aly, Ahmed S., Kappe, Stefan H. I., Harty, John T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3117254/
https://ncbi.nlm.nih.gov/pubmed/21669394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2011.05.008
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