Chemotherapy overcomes TRAIL-R4-mediated TRAIL resistance at the DISC level

TNF-related apoptosis-inducing ligand or Apo2L (Apo2L/TRAIL) is a promising anti-cancer drug owing to its ability to trigger apoptosis by binding to TRAIL-R1 or TRAIL-R2, two membrane-bound receptors that are often expressed by tumor cells. TRAIL can also bind non-functional receptors such as TRAIL-...

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Detalhes bibliográficos
Main Authors: Morizot, A, Mérino, D, Lalaoui, N, Jacquemin, G, Granci, V, Iessi, E, Lanneau, D, Bouyer, F, Solary, E, Chauffert, B, Saas, P, Garrido, C, Micheau, O
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3117243/
https://ncbi.nlm.nih.gov/pubmed/21072058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2010.144
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