C4-methyldeoxythymidine replacing deoxythymidine in poly[d(A-T)] renders the polymer resistant to the 3'----5' exonuclease activity of the Klenow and T4 DNA polymerases.

Ítems similars

• Escherichia coli polymerase I can use O2-methyldeoxythymidine or O4-methyldeoxythymidine in place of deoxythymidine in primed poly(dA-dT).poly(dA-dT) synthesis.
  per: Singer, B, et al.
  Publicat: (1983)
• The effect of the 3',5' thiophosphoryl linkage on the exonuclease activities of T4 polymerase and the Klenow fragment.
  per: Gupta, A P, et al.
  Publicat: (1984)
• Inhibition of Klenow DNA polymerase and poly(A)-specific ribonuclease by aminoglycosides.
  per: Ren, Yan-Guo, et al.
  Publicat: (2002)
• The incorporation of O6-methyldeoxyguanosine and O4-methyldeoxythymidine monophosphates into DNA by DNA polymerases I and alpha.
  per: Hall, J A, et al.
  Publicat: (1983)
• N4-Methoxydeoxycytidine triphosphate is in the imino tautomeric form and substitutes for deoxythymidine triphosphate in primed poly d[A-T] synthesis with E. coli DNA polymerase I.
  per: Singer, B, et al.
  Publicat: (1984)