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Toxoplasma gondii inhibits granzyme B-mediated apoptosis by the inhibition of granzyme B function in host cells

Host defense to the apicomplexan parasite Toxoplasma gondii is critically dependent on CD8(+) T cells, whose effector functions include the induction of apoptosis in target cells following the secretion of granzyme proteases. Here we demonstrate that T. gondii induces resistance of host cells to apo...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Yamada, Tatsuya, Tomita, Tadakimi, Weiss, Louis M., Orlofsky, Amos
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3116727/
https://ncbi.nlm.nih.gov/pubmed/21329693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpara.2010.11.012
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