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Intracellular parasitism with Toxoplasma gondii stimulates mTOR-dependent host cell growth despite impaired signaling to S6K1 and 4E-BP1

The Ser/Thr kinase mTOR is a central regulator of anabolism, growth and proliferation. We investigated the effects of Toxoplasma gondii on host mTOR signaling. Toxoplasma invasion of multiple cell types rapidly induced sustained mTOR activation that was restricted to infected cells, as determined by...

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Detalhes bibliográficos
Main Authors: Wang, Yubao, Weiss, Louis M., Orlofsky, Amos
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2880858/
https://ncbi.nlm.nih.gov/pubmed/19302577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1462-5822.2009.01305.x
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