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Intracellular parasitism with Toxoplasma gondii stimulates mTOR-dependent host cell growth despite impaired signaling to S6K1 and 4E-BP1
The Ser/Thr kinase mTOR is a central regulator of anabolism, growth and proliferation. We investigated the effects of Toxoplasma gondii on host mTOR signaling. Toxoplasma invasion of multiple cell types rapidly induced sustained mTOR activation that was restricted to infected cells, as determined by...
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| Asıl Yazarlar: | , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2009
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2880858/ https://ncbi.nlm.nih.gov/pubmed/19302577 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1462-5822.2009.01305.x |
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