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Targeted gene correction using psoralen, chlorambucil and camptothecin conjugates of triplex forming peptide nucleic acid (PNA)

Gene correction activation effects of a small series of triplex forming peptide nucleic acid (PNA) covalently conjugated to the DNA interacting ligands psoralen, chlorambucil and camptothecin targeted proximal to a stop codon mutation in an EGFP reporter gene were studied. A 15-mer homopyrimidine PN...

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Autors principals: Birkedal, Henrik, Nielsen, Peter E
Format: Artigo
Idioma:Inglês
Publicat: Landes Bioscience 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3116579/
https://ncbi.nlm.nih.gov/pubmed/21686249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/adna.2.1.15553
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