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Novel Natural Inhibitors of CYP1A2 Identified by in Silico and in Vitro Screening

Inhibition of cytochrome P450 (CYP) is a major cause of herb–drug interactions. The CYP1A2 enzyme plays a major role in the metabolism of drugs in humans. Its broad substrate specificity, as well as its inhibition by a vast array of structurally diverse herbal active ingredients, has indicated the p...

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Detalles Bibliográficos
Main Authors: Zhu, Ruixin, Hu, Liwei, Li, Haiyun, Su, Juan, Cao, Zhiwei, Zhang, Weidong
Formato: Artigo
Idioma:Inglês
Publicado: Molecular Diversity Preservation International (MDPI) 2011
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3116189/
https://ncbi.nlm.nih.gov/pubmed/21686183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms12053250
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