Primary breast cancer patients with high risk clinicopathologic features have high percentages of bone marrow epithelial cells with ALDH activity and CD44(+)CD24(lo) cancer stem cell phenotype

BACKGROUND: Cancer stem cells (CSCs) are purported to be epithelial tumor cells expressing CD44(+)CD24(lo) that exhibit aldehyde dehydrogenase activity (Aldefluor(+)). We hypothesized that if CSCs are responsible for tumor dissemination, disseminated cells in the bone marrow (BM) would be positive f...

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Autors principals: Reuben, James M., Lee, Bang-Ning, Gao, Hui, Cohen, Evan N., Mego, Michel, Giordano, Antonio, Wang, Xuemei, Lodhi, Ashutosh, Krishnamurthy, Savitri, Hortobagyi, Gabriel N., Cristofanilli, Massimo, Lucci, Anthony, Woodward, Wendy A.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3116032/
https://ncbi.nlm.nih.gov/pubmed/21334874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejca.2011.01.011
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