Preferential Activation of SMAD1/5/8 on the Fibrosa Endothelium in Calcified Human Aortic Valves - Association with Low BMP Antagonists and SMAD6

BACKGROUND: Aortic valve (AV) calcification preferentially occurs on the fibrosa side while the ventricularis side remains relatively unaffected. Here, we tested the hypothesis that side-dependent activation of bone morphogenic protein (BMP) pathway in the endothelium of the ventricularis and fibros...

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Detalhes bibliográficos
Main Authors: Ankeny, Randall F., Thourani, Vinod H., Weiss, Daiana, Vega, J. David, Taylor, W. Robert, Nerem, Robert M., Jo, Hanjoong
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3115968/
https://ncbi.nlm.nih.gov/pubmed/21698246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0020969
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