The nucleoporin RanBP2 tethers the cAMP effector Epac1 and inhibits its catalytic activity

Cyclic adenosine monophosphate (cAMP) is a second messenger that relays a wide range of hormone responses. In this paper, we demonstrate that the nuclear pore component RanBP2 acts as a negative regulator of cAMP signaling through Epac1, a cAMP-regulated guanine nucleotide exchange factor for Rap. W...

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Bibliografiske detaljer
Main Authors: Gloerich, Martijn, Vliem, Marjolein J., Prummel, Esther, Meijer, Lars A.T., Rensen, Marije G.A., Rehmann, Holger, Bos, Johannes L.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2011
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3115801/
https://ncbi.nlm.nih.gov/pubmed/21670213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201011126
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