Mouse ES cells overexpressing DNMT1 produce abnormal neurons with upregulated NR1

High levels of DNA methyltransferase 1 (DNMT1), hypermethylation, and downregulation of GAD(67) and reelin have been described in GABAergic interneurons of patients with schizophrenia (SZ) and bipolar (BP) disorders. However, overexpression of DNMT1 is lethal, making it difficult to assess the direc...

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Autors principals: D'Aiuto, Leonardo, Di Maio, Roberto, Mohan, K. Naga, Minervini, Crescenzio, Saporiti, Federica, Soreca, Isabella, Greenamyre, J. Timothy, Chaillet, J. Richard
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3115397/
https://ncbi.nlm.nih.gov/pubmed/21492995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.diff.2011.03.003
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