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Threonine 48 in the BIR domain of survivin is critical to its mitotic and anti-apoptotic activities and can be phosphorylated by CK2 in vitro

In this study we report that the protein kinase CK2 phosphorylates survivin specifically on threonine 48 (T48) within its BIR domain, and that T48 is critical to both the mitotic and anti-apoptotic roles of survivin. Interestingly, during mitosis T48 mutants localise normally, but are unable to supp...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Barrett, Rachel MA, Colnaghi, Rita, Wheatley, Sally P
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Landes Bioscience 2011
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3115020/
https://ncbi.nlm.nih.gov/pubmed/21252625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.10.3.14758
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