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Survivin reads phosphorylated histone H3 threonine 3 to activate the mitotic kinase Aurora B
A hallmark of mitosis is the appearance of high levels of histone phosphorylation, yet the roles of these modifications remain largely unknown. Here we demonstrate that histone H3 phosphorylated at threonine 3 is directly recognized by an evolutionarily conserved binding pocket in the BIR domain of...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3177562/ https://ncbi.nlm.nih.gov/pubmed/20705815 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1189505 |
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