IL-15 ex vivo overcomes CD4(+) T cell deficiency for the induction of human antigen-specific CD8(+) T cell responses

CD4(+) Th cells are important for the induction and maintenance of antigen-specific CD8(+) T cell function, so their loss or dysfunction in HIV-infected or cancer patients could reduce the patients' ability to control viral infection. Previous work in murine systems indicated that IL-15 codeliv...

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Bibliographische Detailangaben
Hauptverfasser: Yu, Huifeng, Tawab-Amiri, Abdul, Dzutsev, Amiran, Sabatino, Marianna, Aleman, Karen, Yarchoan, Robert, Terabe, Masaki, Sui, Yongjun, Berzofsky, Jay A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Leukocyte Biology 2011
Schlagworte:
Translational & Clinical Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3114597/
https://ncbi.nlm.nih.gov/pubmed/21474552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.1010579
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