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Telomeres, stem cells, senescence, and cancer
Mammalian aging occurs in part because of a decline in the restorative capacity of tissue stem cells. These self-renewing cells are rendered malignant by a small number of oncogenic mutations, and overlapping tumor suppressor mechanisms (e.g., p16(INK4a)-Rb, ARF-p53, and the telomere) have evolved t...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2004
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC311439/ https://ncbi.nlm.nih.gov/pubmed/14722605 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200420761 |
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