Lack of Interleukin-1 Receptor I (IL-1RI) Protects Mice From High-Fat Diet–Induced Adipose Tissue Inflammation Coincident With Improved Glucose Homeostasis

OBJECTIVE: High-fat diet (HFD)-induced adipose tissue inflammation is a critical feature of diet-induced insulin resistance (IR); however, the contribution of interleukin-1 receptor I (IL-1RI)-mediated signals to this phenotype has not been defined. We hypothesized that lack of IL-1RI may ameliorate...

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Autors principals: McGillicuddy, Fiona C., Harford, Karen A., Reynolds, Clare M., Oliver, Elizabeth, Claessens, Mandy, Mills, Kingston H.G., Roche, Helen M.
Format: Artigo
Idioma:Inglês
Publicat: American Diabetes Association 2011
Matèries:
Obesity Studies
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3114387/
https://ncbi.nlm.nih.gov/pubmed/21515850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db10-1278
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