Immunization of mice with the non-toxic HC50 domain of botulinum neurotoxin presented by rabies virus particles induces a strong immune response affording protection against high-dose botulinum neurotoxin challenge

We previously showed that rabies virus (RABV) virions are excellent vehicles for antigen presentation. Here, a reverse genetic approach was applied to generate recombinant RABV that express a chimeric protein composed of the heavy chain carboxyterminal half (HC50) of botulinum neurotoxin type A (BoN...

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Detalhes bibliográficos
Main Authors: Mustafa, Waleed, Al-Saleem, Fetweh H., Nasser, Zidoon, Olson, Rebecca M., Mattis, Jeffrey A., Simpson, Lance L., Schnell, Matthias J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3114282/
https://ncbi.nlm.nih.gov/pubmed/21549784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2011.04.045
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