Molecular Dynamics Simulations of Viral RNA Polymerases Link Conserved and Correlated Motions of Functional Elements to Fidelity

The viral RNA-dependent RNA polymerase (RdRp) is essential for multiplication of all RNA viruses. The sequence diversity of an RNA virus population contributes to its ability to infect the host. This diversity emanates from errors made by the RdRp during RNA synthesis. The physical basis for RdRp fi...

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Bibliographic Details
Main Authors: Moustafa, Ibrahim M., Shen, Hujun, Morton, Brandon, Colina, Coray M., Cameron, Craig E.
Format: Artigo
Language:Inglês
Published: Elsevier Ltd. 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3114172/
https://ncbi.nlm.nih.gov/pubmed/21575642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.04.078
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