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Inactivation of menin, a Smad3-interacting protein, blocks transforming growth factor type β signaling

Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder characterized by endocrine tumors of parathyroids, pancreatic islets, and anterior pituitary. The MEN1 gene encodes a nuclear protein called menin. In MEN1 carriers inactivating mutations give rise to a truncated product co...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Kaji, Hiroshi, Canaff, Lucie, Lebrun, Jean-Jacques, Goltzman, David, Hendy, Geoffrey N.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2001
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC31139/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11274402/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.061358098
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