Histone deacetylase activity is necessary for left-right patterning during vertebrate development

BACKGROUND: Consistent asymmetry of the left-right (LR) axis is a crucial aspect of vertebrate embryogenesis. Asymmetric gene expression of the TGFβ superfamily member Nodal related 1 (Nr1) in the left lateral mesoderm plate is a highly conserved step regulating the situs of the heart and viscera. I...

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Main Authors: Carneiro, Katia, Donnet, Claudia, Rejtar, Tomas, Karger, Barry L, Barisone, Gustavo A, Díaz, Elva, Kortagere, Sandhya, Lemire, Joan M, Levin, Michael
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2011
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3113753/
https://ncbi.nlm.nih.gov/pubmed/21599922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-213X-11-29
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