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Nitric Oxide Modulates TGF-β–Directive Signals To Suppress Foxp3(+) Regulatory T Cell Differentiation and Potentiate Th1 Development
TGF-β can induce Foxp3(+) inducible regulatory T cells (Treg) and also synergize with IL-6 and IL-4 to induce Th17 and Th9 cells. We now report that NO modulates TGF-β activity away from Treg but toward the Th1 lineage. NO potentiated Th1 differentiation in the presence of TGF-β in both IL-12–indepe...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3113707/ https://ncbi.nlm.nih.gov/pubmed/21555530 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1100485 |
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