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Toll-like receptor activation of XBP1 regulates innate immune responses in macrophages

Sensors of pathogens, such as Toll-like receptors (TLRs), detect microbes to activate transcriptional programs that orchestrate adaptive responses to specific insults. Here we report that TLR4 and TLR2 specifically activated the endoplasmic reticulum (ER)-stress sensor kinase IRE1α and its downstrea...

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Detalhes bibliográficos
Main Authors: Martinon, Fabio, Chen, Xi, Lee, Ann-Hwee, Glimcher, Laurie H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3113706/
https://ncbi.nlm.nih.gov/pubmed/20351694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1857
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