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Discovery and Canine Preclinical Assessment of a Non-Toxic Procaspase-3-Activating Compound
A critical event in the apoptotic cascade is the proteolytic activation of procaspases to active caspases. The caspase auto-activating compound PAC-1 induces cancer cell apoptosis and exhibits antitumor activity in murine xenograft models when administered orally as a lipid-based formulation or impl...
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| Autori principali: | , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3113694/ https://ncbi.nlm.nih.gov/pubmed/20823163 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-0766 |
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