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Transgenic overexpression of the α7 integrin reduces muscle pathology and improves viability in the dy(W) mouse model of merosin-deficient congenital muscular dystrophy type 1A

Merosin-deficient congenital muscular dystrophy 1A (MDC1A) is a devastating neuromuscular disease that results in children being confined to a wheelchair, requiring ventilator assistance to breathe and premature death. MDC1A is caused by mutations in the LAMA2 gene, which results in the partial or c...

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Bibliografski detalji
Glavni autori: Doe, Jinger A., Wuebbles, Ryan D., Allred, Erika T., Rooney, Jachinta E., Elorza, Margaret, Burkin, Dean J.
Format: Artigo
Jezik:Inglês
Izdano: Company of Biologists 2011
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3113674/
https://ncbi.nlm.nih.gov/pubmed/21652631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.083311
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