GRK2 Activity Impairs Cardiac Glucose Uptake and Promotes Insulin Resistance Following Myocardial Ischemia

BACKGROUND: Alterations in cardiac energy metabolism downstream of neurohormonal stimulation play a crucial role in the pathogenesis of heart failure (HF). The chronic adrenergic stimulation that accompanies HF is a signaling abnormality that leads to the up-regulation of G protein-coupled receptor...

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Detalhes bibliográficos
Main Authors: Ciccarelli, Michele, Chuprun, J. Kurt, Rengo, Giuseppe, Gao, Erhe, Wei, Zhengyu, Peroutka, Raymond J., Gold, Jessica, Gumpert, Anna, Chen, Mai, Otis, Nicholas J., Dorn, Gerald W., Trimarco, Bruno, Iaccarino, Guido, Koch, Walter J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3113597/
https://ncbi.nlm.nih.gov/pubmed/21518983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.110.988642
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