Comparative whole genome sequencing reveals phenotypic tRNA gene duplication in spontaneous Schizosaccharomyces pombe La mutants

We used a genetic screen based on tRNA-mediated suppression (TMS) in a Schizosaccharomyces pombe La protein (Sla1p) mutant. Suppressor pre-tRNA(Ser)UCA-C47:6U with a debilitating substitution in its variable arm fails to produce tRNA in a sla1-rrm mutant deficient for RNA chaperone-like activity. Th...

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Detalhes bibliográficos
Main Authors: Iben, James R., Epstein, Jonathan A., Bayfield, Mark A., Bruinsma, Monique W., Hasson, Samuel, Bacikova, Dagmar, Ahmad, Daniel, Rockwell, Denise, Kittler, Ellen L. W., Zapp, Maria L., Maraia, Richard J.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
Assuntos:
Genomics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3113579/
https://ncbi.nlm.nih.gov/pubmed/21317186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr066
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